Medicines

Pentamidine: Uses, Mechanism of Action, Side Effects, and Contraindications

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Pentamidine

What is Pentamidine? The drug Pentamidine is broadly classified under anti-protozoal drugs. Several diamidine compounds have trypanocidal action, including pentamidine. In the treatment of visceral leishmaniasis, pentamidine isethionate is utilized instead of sodium stibogluconate. It can also be used to treat early trypanosomiasis. Pentamidine Mechanism of Action The precise mechanism has yet to be discovered. … Read more

Eflornithine: Mechanism of Action, Uses, Side effects, and Contraindications

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Eflornithine

Difluoromethylornithine DFMO which is now commonly known as Eflornithine shows clinical efficacy against Pneumocystis pneumonia (PCP) and West African trypanosomiasis. The drug was initially designed to be used as an anticancer agent, but it proved to be unproductive later. African sleeping sickness, which is also known as Human African trypanosomiasis, is a parasite infection transmitted … Read more

Sulfasalazine: Side Effects, Interactions, and Uses

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Sulfasalazine

What is Sulfasalazine? A prodrug: sulfasalazine, is used in the treatment of chronic inflammatory bowel disease and to treat rheumatoid arthritis as second-line therapy. It’s composed of sulfapyridine and 5-aminosalicylic acid (5-ASA) connected by an azo bond, which is broken by bacteria in the distal ileum and colon to release the active ingredients. In the … Read more

Azulfidine: Uses, Active ingredient, and Warnings

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Azulfidine

What is Azulfidine? Azulfidine is a brand name of the drug, containing Sulfasalazine as an active ingredient. Sulfasalazine is known to possess anti-inflammatory activity and is thus used to treat Rheumatoid arthritis. It is a prescription-only medication. Generic name Sulfasalazine (Drug class: Anti-inflammatory, Disease-modifying antirheumatic drugs (DMARDs), 5-Aminosalicylic acid derivatives) Sulfasalazine (Azulfidine) available dosage forms … Read more

Lampit (Nifurtimox Tablets): Uses, Contraindications, and Side Effects

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Lampit

What is LAMPIT and why it is used? Lampit is nifurtimox-containing tablets. Nifurtimox is classified as an antiprotozoal drug used to treat Chagas disease which is caused by Trypanosoma cruzi. Active Ingredient Active ingredient of Lampit is Nifurtimox. LAMPIT Contraindications Patients who have a known hypersensitivity to nifurtimox or any of the excipients in LAMPIT, … Read more

Sulfasalazine and Folic Acid Concomitant Use: When and Why?

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sulfasalazine and folic acid

What is Sulfasalazine? Sulfasalazine/sulphasalazine is a sulphonamide (amino salicylic acid molecule) that is approved for the treatment of active Crohn’s disease and rheumatoid arthritis, as well as the induction and management of remission in ulcerative colitis. What is Folic Acid? Folic Acid is also sometimes named Vitamin B9. It is man-made folate. It is considered one of … Read more

Nifurtimox: Mechanism of Action, Uses, Interactions, and Adverse Effects

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Nifurtimox

Benznidazole and Nifurtimox The trypanosomatid parasite Trypanosoma cruzi causes Chagas disease, which threatens millions of people in South America. As with other neglected diseases, there is essentially no pharmaceutical industry research and development effort, and treatment is based on two medications, Nifurtimox and Benznidazole, which were found empirically more than thirty years ago. Nifurtimox Mechanism … Read more

Sulfasalazine vs Mesalamine: Treatment of Crohn’s Disease Remission

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Sulfasalazine vs Mesalamine

What is Crohn’s disease? Crohn’s disease is a “chronic inflammatory disease” that can harm a person’s quality of life if it is discovered during their formative years. This condition has a significant economic impact, with annual costs ranging from $1.2 billion to $6.1 billion in Canada and the US, respectively. The natural history of Crohn’s … Read more